CJC-1295 Peptide (No DAC)

CJC-1295 is a synthetic peptide analog of the naturally occurring growth hormone-releasing hormone (GHRH) and is composed of 29 amino acids. It is also referred to as Modified GRF (1-29) or CJC-1295 without DAC. This version of the peptide contains four substituted amino acids designed to reduce degradation, but unlike CJC-1295 DAC, it does not include a Drug Affinity Complex, meaning its half-life is naturally shorter without additional stabilization.

The initial discovery of the GRF (1-29) fragment occurred in the early 1980s, when researchers determined that the first 29 amino acids of GHRH retained the biological activity of the full 44-amino acid hormone. One of the main limitations of early synthetic GHRH fragments was their short half-life, but ongoing research has produced a stabilized form of CJC-1295 without DAC that is more durable and suitable for research purposes.

Overview

CJC-1295 without DAC, also known as tetra-substituted GRF (1-29), is a synthetic version of GHRH engineered to stimulate growth hormone secretion. It consists of the minimal sequence required to bind to GHRH receptors, specifically the first 29 amino acids of GHRH, with four key amino acids altered to enhance stability and resist enzymatic breakdown, particularly by dipeptidyl peptidase-4 (DPP-4).

The amino acid substitutions include:

• Position 2: L-alanine replaced with D-alanine to increase resistance to molecular degradation.

• Position 8: Asparagine replaced with glutamine to reduce amide hydrolysis and maintain structural integrity.

• Position 15: Glycine replaced with alanine to enhance peptide bioactivity.

• Position 27: Methionine replaced with leucine to prevent oxidation and improve stability.

Chemical Makeup

• Molecular Formula: C152H252N44O42

• Molecular Weight: 3367.9 g/mol

• Other Known Titles: CJC-1295 Without DAC